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Design, synthesis and evaluation of highly stereoselective chiral selectors to be used for enantiomer separations by membrane methodologies

Objective



Research objectives and content
The objective of the present proposal is the development of new Liquid Supported Membranes (LSM) from chiral selectors of high lipophilicity. These molecules should be designed by molecular modeling, tested with different techniques, and modified, if necessary, in basis to their chiral recognition ability to obtain high selectivity factors for the separation of enantiomers. Later, they would be highly lipophilised to be used as 'chiral additives' in LSM technology. The resulting chiral membranes would be optimized, in order to maximize its performance, stability and producibility rates, and used for preparative enantioseparations. Training content (objective, benefit and expected impact)
The project would add to the actual experience of the applicant the knowledge and training in several technical and scientific disciplines such as molecular modeling, new synthetic procedures and, obviously, membrane technology. All these elements ensure a broad training programme that would be of an important impact either for the European industry, due to the potential applications of the membranes envisaged, and for the applicant, due to the quality of the scientific research to be developed. Links with industry / industrial relevance (22)
The host institution is cooperating with pharmaceutical industry in this project that has the granted Brite Euram EU Project on Chiral Membranes. The research results would be of industrial relevance, because chiral membranes should be highly interesting tools for the separation of enantiomers.

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

UNIVERSITY OF VIENNA
Address
38,Wahringer Strasse 38
1010 Wien
Austria

Participants (1)

Not available
Spain