Objective
Research objectives and content
The immunological mechanisms to distinguish self from nonself (tolerance) are a major topic in current immunology. Currently dominating views explain this phenomenon with mechanisms based on the physical and/or functional inactivation of autoreactive cells. However, these views fail in the attempt to explain certain observations like curing diseases through the transfer of cells from a healthy donor or the existence of functionally active, autoreactive T cells in vivo. In addition, there exists a large body of evidence for the existence of regulatory T cells which are responsible for the maintenance of tolerance in a normal animal, but so far these cells have not been fully characterized. In the proposed project it will be tried to characterise regulatory T cells with regard to their development inside the thymus and their behaviour in maintaining tolerance to peripheral selfantigens.
Training content (objective, benefit and expected impact)
The nature of the topic includes the application of almost all different methods available in cellular immunology, including standard methods as well as specialized techniques set up by the Pasteur Institute. Therefore, this project contains not only a very good education itself, but allows also the possibility for a broad application afterwards. The work will be carried out in the frame of a doctoral thesis.
Links with industry / industrial relevance (22)
In investigating important basic mechanisms of tolerance the expected results will strongly support solutions for problems in the field of transplantation medecine and the treatment of autoimmune diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology autoimmune diseases
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75724 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.