Objective
Research objectives and content
The objective of this project is the study of the mechanism that control cell-fate determination in early neurogenesis, using the chicken retina as a model system. Neurons of the vertebrate central nervous system are generated from dividing neuroepithelial progenitors cells. Lateral inhibition mediated by the neurogenic genes Delta and Notch is required to maintain these proliferating progenitors so that neurogenesis can continue. Our project approach the study of the role in vivo of
mitogen-activated protein kinases (MAPKs) pathway and extrinsic signals (growth factors such as EGF, NT-3 and IGF-I) in cell-fate determination and the correlation of this pathway with the mechanism of lateral inhibition modulated by the Delta/Notch signalling. For this purpose we are planning to use retrovirus-mediated gene misexpression to interfere with the MAPK pathway and the extrinsic signals mentioned above.
Training content (objective, benefit and expected impact) The project will provide training in different theoretical aspects of neurogenesis, signal transduction and gene regulation and a practical approach in a variety of molecular and cellular techniques, such as the alteration of gene expression using retrovirus. In addition I will benefit intellectually and practically from interactions with other ICRF laboratories that work on signal transduction and developmental neurobiology.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine ophthalmology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2 3PX LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.