Virus-like particles in plasmodium - a potential role in the evasion of the mosquito immune response

Informations projet

N° de convention de subvention: FMBI972756

Projet clôturé

Date de début 1 Mai 1998

Date de fin 30 Avril 2000

Financé au titre de

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Coût total Aucune donnée

Contribution de l’UE Aucune donnée

Coordonné par

Institut Pasteur
France

Objectif

Research objectives and content
Plasmodia are mosquito-borne protozoa which cause malaria. For successful transmission, the protozoa must evade the mosquito immune response. Insect endoparasites (endoparasitoids) suppress the immune system, specifically the encapsulation response, of their insect hosts by utilising viruses and virus-like particles (VLPs). Plasmodia are also known to contain VLPs, exclusively during stages of its lifecycle which occur within the mosquito vector. Morphological, cytochemical and molecular characterisation will reveal the true nature of the VLPs within Plasmodium and provide the basis for the assessment of their role in immune evasion.
Training content (objective, benefit and expected impact)
Dr.Brey's research group at the Pasteur Institute, which is currently researching the molecular biology and biochemistry of encapsulation within the anopheline malaria vectors, provides a unique opportunity to carry out this proposal. In addition, the extensive expertise in microbiology at the Pasteur Institute, especially in the fields of electron microscopy and virology will give me an opportunity to learn new techniques and explore novel approaches to the study of the parasite-vector relationship. Collaboration with this research group would allow me to broaden the knowledge of vector-parasite interactions acquired as part of my PhD and explore novel mechanisms to combat malaria through the application of a challenging new approach.
Links with industry / industrial relevance (22)

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• sciences médicales et de la santé › sciences de la santé › maladie infectieuse › paludisme
• sciences naturelles › sciences biologiques › microbiologie › virologie
• sciences naturelles › sciences biologiques › microbiologie › protozoologie
• sciences médicales et de la santé › médecine fondamentale › immunologie
• sciences naturelles › sciences biologiques › zoologie › zoologie des invertébrés

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Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Thème(s)

• 0302 - Post-doctoral research training grants
• TL04 - Microbiology (Virology inc. AIDS)

Appel à propositions

Données non disponibles

Régime de financement

RGI -

Coordinateur

Institut Pasteur

• Contribution de l’UE: Aucune donnée
• Adresse: 28,Rue du Docteur Roux ; 75724 Paris ; France
• Coût total: Aucune donnée

Participants (1)

Not available

Royaume-Uni

• Contribution de l’UE: Aucune donnée
• Coût total: Aucune donnée