Objective
Research objectives and content
Axonal pathfinding in the nervous system is mediated in part by cell-to-cell signaling events involving members of the Eph receptor tyrosine kinase family and their membrane-bound ligands. The research objective is to establish the role of the ligand EphrinB 1 in the pathfinding of neurons within the mammalian nervous system. The first part of the research plan is to knock-out the Ephrin-B 1 gene to establish the significance of this ligand in directing axon guidance as well as the involvement of this geneproduct in border formation and migration of nerve cells. In a second project, we will produce a knock-in construct in which exonic sequences of Ephrin-B 1 will be replaced by an Ephrin-B 1 cDNA lacking the cytoplasmic domain (EphrinB 1-DeltaC). Analysis of such mice will supply genetic evidence for the importance of Eph-receptor induced ligand-signaling by use of the cytoplasmic domain of the ligand. Training content (objective, benefit and expected impact)
The objective is to receive experience in the generation of genetic models to investigate complicated molecular interactions in the central nervous system. Several benefits are at hand, such as the establishment of fruitful interactions and the first-class training in an expanding and innovative area of neuroscience research. The training is expected to significantly increase the applicants knowledge in the field of neuroscience, and in particular of the organisation and requirements of cell-to-cell signaling in the central nervous system. The training will provide an excellent foundation for future research.
Links with industry / industrial relevance (22)
No present links with industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69012 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.