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Catalytic asymmetric oxidation of sulfides to sulfoxides and the investigation of non-linear effects and kinetic resolution


Research objectives and content
Asymmetric epoxidation of allylic alcohols with a titanium-tartrate catalyst, according to Sharpless, has became one of the most powerful methods in organic synthesis. However, the structure of the complex is, despite several years of intensive research, not known in detail. In our laboratory we are developing catalytic oxidation of sulfides to the concerning sulfoxides, using a modified 'Sharpless catalyst'. To investigate further the details of our system and to find out more about the structure of the catalyst, we now intend to use our experience with non-linear effects and autoinduction. The aim of the proposal is to develop new more powerful and more general catalysts as well as to develop these new 'analytical tools'. Moreover we intend to investigate possibilities to use kinetic resolution in order to find out an easy way to reach optically pure sulfoxides.
Training content (objective, benefit and expected impact)
In Kagan's group the candidate will benefit from first-class training both experimental and theoretical aspects of the asymmetric synthesis and stereochemistry. He will also receive higher degree of the education. Links with industry / industrial relevance (22)
The candidate has a scholarship of the Neste co. (Finland) for 1997. Rhtne-Poulenc co. (France) has financed post-docs in asymmetric sulfoxidation and also scaled-up reactions similar to the one developed in Kagan's laboratory.

Appel à propositions

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Université de Paris-Sud XI
Contribution de l’UE
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91405 Orsay

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Participants (1)