Objective
Research objectives and content
To generate efficient protection against chronic infections such as parasitic diseases, controlling pathology could be more relevant than controlling the infection itself. In chronic schistosomiasis, the major pathological hallmarks are hepatic granuloma formation and fibrosis due to the accumulation of viable eggs in liver. Limitation of local inflammatory reactions associated with or without reduction in worm fecundity and in worm burden may be a goal for vaccine development. Our approach will be based on unexpected effects of B subunit of cholera toxin (CTB), known for its mucosal adjuvant effects, which also strongly induces oral tolerance for directly linked antigens. In this proposal, we plan to test whether the mucosal administration of schistosomal antigens coupled to recombinant CTB can suppress antigen-specific and bystander T-cell mediated DTH inflammatory reactions in a way that could suppress immunopathological consequences of schistosome product deposition in host tissues. Training content (objective, benefit and expected impact)
This project will allow me to acquire competence on new cellular immune technologies and to improve my knowledge on mucosal immunology and mucosal vaccines.
Links with industry / industrial relevance (22)
The expected results should allow critical evaluation of the feasibility of future vaccination trials dedicated to reduction of immunopathology during parasitic infections and could provide economic opportunities for EC companies to manufacture recombinant vaccines.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
413 46 Gfteborg
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.