Objective
Research objectives and content The permeability of the blood-brain barrier has been shown to be influenced by several mediators, including hormones but also inflammatory mediators. Understanding the underlying mechanisms may contribute to the development of methods for blood-brain barrier opening, as a therapeutic strategy for some central nervous system disorders. The present project is for studying receptor-and channel-mediated changes in intracellular calcium, as well as activation or inhibition of membrane currents, in response to different mediators involved in normal physiology of brain endothelial cells and in inflammation. Links between each of these events and between them and functional properties of the barrier will be also investigated. The results will contribute to understand the cellular events involved in the regulation of endothelium permeability, and will help to explain the synergistic effects of chemical mediators in physiology and pathology. Training content (objective, benefit and expected impact)
My first objective is to work on a project linking my two fields of interest (i.e. blood-brain barrier biology and signal transduction) and offering a medical aspect. My second one is to learn the advanced techniques developed by Dr Abbott's group (simultaneous calcium monitoring and patch clamp recording; flash photolysis for release of second messengers). And the third one is to improve my fluency in English. I think that the project will allow me to achieve all these objectives. Links with industry / industrial relevance (22)
This project is relevant to the interests of the pharmaceutical industry, because of its implications for drug delivery to the brain.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2R 2LS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.