Objective
Research objectives and content Human and bovine TB are important problems. BCG vaccination has been used to combat human disease and is under consideration for control of animal disease. However, BCG has been unreliable in some circumstances and new vaccines are required urgently. Logical vaccine development requires precise understanding of protective immunity. Previous studies have often used unnatural modes of disease, or have ignored the crucial immune events at the site of infection/immunization. It is the objective of this study to apply the latest technology to define the local immune responses which occur in a natural model of TB in cattle. Surgical procedures will be used to harvest lymphatic T-cells after stimulation of local anti-TB immunity. Molecular immunological techniques and flow cytometry will be used to assess the function and classification of these cells in precise detail. This information will allow comparison of local responses to TB and any candidate vaccine. Training content (objective, benefit and expected impact) A primary objective is to provide training in all aspects of current immunological research (flow cytometry, lymphocyte functions, molecular immunology, Iymphatic cannulation etc.). Benefits of the training will be a researcher with very broad experience and potential to have considerable impact on TB research (considered of high priority in the EU). The benefits and impact from this proposal will include the development of a local model of infection which will be a valuable tool for assessment of novel candidate vaccines. The project will provide an increased understanding of both human and bovine tuberculosis. Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology immunisation
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences clinical medicine surgery surgical procedures
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- agricultural sciences animal and dairy science domestic animals animal husbandry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BT4 3SD BELFAST
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.