Objective
Research objectives and content Clathrin-coated vesicle formation leads to the receptor-mediated endocytosis of extracellular macromolecules. The mechanism which regulates the formation of such vesicles is poorly understood. Clathrin, adaptors, ATP and cytosol are all required for the formation of these vesicles. One of the cytosolic components required for coated pit invagination has been identified as rab5-rabGDI, a component previously demonstrated to be important for membrane dynamics at later stages of the endocytic pathway. The processes of transport vesicle formation and subsequent fusion therefore appear to be linked. The aim of this project is to further define the role of rab5 in clathrin-coated pit formation using biochemical and morphological approaches. These studies should yield valuable information, not only about the mechanism of clathrin coated pit assembly but may also have implications for other vesicle trafficking pathways. Training content (objective, benefit and expected impact) Only limited data are available on the regulation of clathrin-coated vesicle formation . This project will lead to a better understanding of this mechanism in elucidating the function of rab5 and interacting proteins. This will ultimately help propose a model for the formation of the clathrin-coated vesicles. This project will provide training in addressing essential question in cell biology using multidisciplinary approach. Links with industry / industrial relevance (22) The research carried out in the host laboratory is basic research into an essential cellular mechanism. At the moment there are no links with industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DD1 4HN DUNDEE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.