Objective Research objectives and content Relatively little is known about the molecular regulation of migration and differentiation of neuronal telencephalic cortical precursors, but it is clear that appropiate cell-adhesion is essential at every stage. Recent studies suggested that the transcription factor, Pax-6, is involved in cortical development. Pilot studies on mice with a mutation of the Pax-6 gene (Small-eye) have suggested that its role is to regulate the adhesive properties of cortical precursor cells. The purpose is understanding Pax-6 function in the developing cortex and study the environmental features of precursor cells, mainly glial morphology. Study will be performed in mutant and wild-type mice using glial markers and in situ hybridization techniques. Additionally mutant and mosaic analysis in chimaeras will be done to elucidate putative cell-autonomous defects in as yet unstudied aspects of Small-eye precursor cells Training content (objective, benefit and expected impact) Training will be focused to learn all methodology required to study the genetic regulation of adhesion, migration and diferentiation processes involved in neuronal developing, and based in mutant and mosaic analysis mainly. Dr.Price,s group has long tradition of research in mouse genetics and analysis of this specific mutant. Also, the methodology for the generation and analysis of chimaeric mice are available at laboratory of Dr.Price. Links with industry / industrial relevance (22) Fields of science natural sciencesbiological sciencesgeneticsmutation Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 0302 - Post-doctoral research training grants TL06 - Developmental Biology Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator University of Edinburgh EU contribution No data Address Teviot Place EH8 9AG Edinburgh United Kingdom See on map Total cost No data
