Objective
Research objectives and content
Relatively little is known about the molecular regulation of migration and differentiation of neuronal telencephalic cortical precursors, but it is clear that appropiate cell-adhesion is essential at every stage. Recent studies suggested that the transcription factor, Pax-6, is involved in cortical development. Pilot studies on mice with a mutation of the Pax-6 gene (Small-eye) have suggested that its role is to regulate the adhesive properties of cortical precursor cells. The purpose is understanding Pax-6 function in the developing cortex and study the environmental features of precursor cells, mainly glial morphology. Study will be performed in mutant and wild-type mice using glial markers and in situ hybridization techniques. Additionally mutant and mosaic analysis in chimaeras will be done to elucidate putative cell-autonomous defects in as yet unstudied aspects of Small-eye precursor cells
Training content (objective, benefit and expected impact)
Training will be focused to learn all methodology required to study the genetic regulation of adhesion, migration and diferentiation processes involved in neuronal developing, and based in mutant and mosaic analysis mainly. Dr.Price,s group has long tradition of research in mouse genetics and analysis of this specific mutant. Also, the methodology for the generation and analysis of chimaeric mice are available at laboratory of Dr.Price.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH8 9AG Edinburgh
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.