Objective
Research objectives and content
Mammalian development requires both parental genomes for normal development. This his is due to imprinted genes whose expression is dependent on their parental origin. The mechanism of marking and subsequent regulation of expression of unprinted genes is unclear. The Hl 9 gene encodes an untranslated RNA transcribed from the matemal allele while the patenna allele is silent. Previous work indicates the presence of a 1.2kb silencer /imprinting element in the 5' region of the Hl9 gene. propose to carry out a detailed molecular aaalysis of tiliS control element. The aim is to identify the essentia'i sequences in the cis element for protein/DNA interaction, and to analyse the specific binding proteins and subsequent protein/protein interactions. This interaction must be a crucial step in the initaition of the unprint.
Training content (objective, benefit and expected impact)
To receive training in molecular developmental biology with spechal reference to epigeneitic modification involved in the imprinting phenomenon.Links with industry / industnal relevance (22) There is growing awareness t'aat epigenetic mechansims of gene regulation are involved in diseases and variations in susceptibility to diseases in indiividuals. The knowledge gained from this work therefore may eventually be crucial in aspects medicine as well as in biotechnology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1QR Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.