Objective
Research objectives and content
The entry of monocytes into the brain may be one of the key events in immune-mediated diseases of the brain, like multiple sclerosis. Interaction of monocytes with the cerebrovascular endothelium may be one of the initial processes in the development of the disease. In this project, the relationship between monocyte-induced signalling pathways within the brain endothelial cells, and the subsequent transmigration of monocytes across the blood-brain barrier will be explored. The study will elucidate the mechanism of monocyte migration at the molecular levelby defining the endothelial surface molecules engaged during the process and which are responsible for initiating signalling pathways leading to alterations in the arrangements of the cytoskeleton and tight junctions. The immortalized cell-lines RBE-4 and GP 8/3 are available within the Institute and form a valuable tool in the transmigration studies. The adhesion molecules involved in the transmigration process will be identified. This project will then focus on the intracellular signalling pathways coupled to these adhesion molecules. In particular the role of small GTP-biding proteins (e.g. rho) in the endothelial cytoskeletal rearrangement and tight junction organisation that occurs during the monocyte transvascular migration will be evaluated.
Training content (objective, benefit and expected impact)
This study will be the first to describe the role and possible correlation of signal transduction pathways and the transmigration of monocytes into the brain. The understanding of these processes may eventually lead to the identification of potential therapies for immune-mediated diseases of the central nervous system.
Links with industry / industrial relevance (22)
This project has no direct links with industry or other Community programmes
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine neurology multiple sclerosis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EC1V 9EL LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.