Objective
Research objectives and content
The overall objective of this project is to develop a Tc-99m based radiopharmaceutical agent for selectively imaging particular dopamine receptor in the brain. The abnormal behaviour of this biological system is associated with a number of important me conditions and a means of measuring the in vivo impact of drugs on this system be great value in optimising the dose needed for effective treatment.The development of the imaging agent will be achieved by incorporating a chelat system capable of binding the Tc-99m radioisotope into a molecule known to bind the D2 receptor. The design of the overall molecule must be such that its metal must be able to cross the blood brain barrier, and the method of attachment of chelate system to the biological active portion of the molecule must be such that does not destroy its ability to bind to the receptor.
Training content (objective, benefit and expected impact)
The proposed project will involve a wide range of chemistry and will provide go training in the design, synthesis and purification of polyfonctional compounds. Experience will be gained in the synthesis of polydentate chelate, use of coupling techniques and protecting groups. In addition, the need to liaise closely with International plc and the Nuclear Medicine team at St. Bartholomew's Hospital in London in connection with labelling and biological testing will provide som ins into the way in which new radio pharmaceuticals are conceived and developed in and the important role that nuclear medicine now plays in diagnostic medicine. Links with industry / industrial relevance (22)
The radio pharmaceutical company Amersham International plc have agreed to participant in the radio-labelling and evaluation of the compounds produced during the course this project as possible radiopharmaceutical imaging agents. This company is al currently funding a postgraduate student in Dr. Griffiths' group working on a complementary project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences clinical medicine radiology nuclear medicine
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EN1 4NS LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.