Objective
Research objectives and content
The host group has previously discovered a novel catalytic cycle for epoxidation of carbonyl compounds using just catalytic quantities of sulfides, metal salts, and diazocompounds (this work was patented by Zeneca). In order to make this process less hazardous, the in situ generation of the diazocompounds has been considered and indeed found to be successful. However, none of the simple chiral sulfides based on oxathianes have worked in the catalytic process and so new classes of chiral sulfides need to be prepared to render this practical, catalytic cycle asymmetric. Once we have found simple chiral sulfides that are effective, we will scale up the process and demonstrate its applicability to the preparation of a broad range of epoxides. In essence, the process constitutes the coupling of two aldehydes to give epoxides with control over relative and absolute stereochemistry and that is atom economical and powerful. This process will also be applied to asymmetric aziridination. Training content (objective, benefit and expected impact)
The chemistry involves the use and handling of sensitive reagents and therefore provides excellent training in careful experimentation. Furthermore, the work will require the use of the all of the most up-to-date analytical techniques and so will provide comprehensive training. The chemistry described could become one of the best methods for the direct preparation of epoxides and this will have a major impact both in academia and industry.
Links with industry / industrial relevance (22)
The host laboratory has strong links with industry (they currently collaborate with 8 different chemical companies) and Sheffield University will be patenting this work if it is successful. Epoxides are intermediates in an increasing number of potential drugs so are critical to the pharmaceutical industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
S3 7HF Sheffield
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.