Objective
Research objectives and content
Depending on environmental conditions, Schizosaccharomyces pombe can enter either pre-mitotic or premiotic DNA synthesis or remain in stationary phase. This decision point is called START. The MBF complex (pgsedololp72resllp73res2) is required for exit from START: it is responsible for the transcription of several genes necessary for entry into the S phase of the cell cycle. However the mechanisms that regulates the complex remain unknown. The main objective of this research project is to determine the contribution of the MBF complex to the cell cycle progression. Further, since cells lacking functional p85cdcl 0 or p73res2 are unable to undergo meiosis, we wish to determine the role of the components of the MBF complex in differentiation. In mamrnalian cells, the complex of the E2F/DP proteins induces the expression of several genes required for S-phase progression. In fact, the E2F/DP and the MBF complexes activate the expression of similar genes, such as ribonucleotide reductase and S-phase cyclins. Thus, even though they lack homology at the molecular level, they can be considered functional homologues. The E2F/DP complex is negatively regulated by the RB family of tumor suppressors. Loss of this regulation leads to premature cell cycle entry that may lead to tumor formation. The characterization of the molecular events that regulate S phase entry in a genetically manipulatable system such as S. pombe may lead to further insights into the regulation of this important cell cycle checkpoint in mammalian cells.
Training content (objective, benefit and expected impact)
During my Ph.D. in Barcelona University and my first postdoctoral experience at the Dana Farber Cancer Institute (Harvard Medical School) I have acquired a strong background in Biochemistry as well as in Molecular Biology. My goal now is to learn Cell Biology and Genetics of yeast, which will help me in the near future at the time of setting my own laboratory. And, to the best of my knowledge, this training can be best achieved at the laboratory of Paul Nurse, which is worldwide known for its excellence in the field of control of the cell cycle in yeast.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics heredity
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2A 3PX London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.