Objective
Research objectives and content
The main objective of this research project is the functional analysis of the RNase H and zinc-finger motifs located in the 3' region of I factor-like elements. These domains, as well as the termination mode, are characteristic of this subgroup of elements and are not included in the present model of transposition of LINE-like elements. The activity of these domains has not even been tested. As a second objective, ) would like to test the hypothesis that I factor-like elements are
retrotranscribed in the cytoplasm.Once established a suitable in vitro transposition system for the I factor element (contract number ERBFMBICT972688), the project will involve the analysis of how site-directed mutation in specific sites of the RNase H and zinc-finger motifs of this element affect its transposition capability.
Training content (objective, benefit and expected impact)
This whole research project will be acquainted me with completely new techniques on molecular biology, like cell culture, making and handling of gene constructs, site-directed mutagenesis and perhaps protein expression and its analysis. The knowledge or this technology can be useful not only for the development of this project but to analyse any other gene. Working on two different research groups, I will benefit from the training ability of both laboratories as well as an specialised supervision on each part of the investigation.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH9 3Jr EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.