Objective
TXT=AB
Research objectives and content
The proposed research sets out to continue the investigation into the use of reversed polarity reagents bearing chiral auxiliaries in the asymmetric synthesis of 1,2- and 1,4-difunctionlised materials as building blocks for organic synthesis.
Enders has recently demonstrated that metalated aminonitriles, derived from aldehydes, and bearing a chiral auxiliary at the amino group, undergo highly diastereoselective 1,4-nucleophilic additions to (a,_)-unsaturated ketones. It is proposed to expand on this methodology by investigating the use of enantiomerically pure metalated aminonitriles derived from (a,_)-unsaturated aldehydes, in additions to both aldehydes and (a,_)-unsaturated carbonyl compounds, in order to access 1,2- and 1,4-difunctionalised materials in high enantiomeric excess. This would provide a useful method for generating chiral alkenoyl anion synthon equivalents
It will be necessary to investigate the influence of steric and electronic factors on the regioselectivity of additions by these ambident nucleophiles as alkenoyl anion or homoenolate equivalents
In addition, it will be necessary to determine the diastereoselectivity of the addition reactions of the alalkenoyl anion equivalents and the enantiomeric purity of their hydrolysis products - expected to be 1,2- and 1,4-difunctionalised ketones.
Training content (objective, benefit and expected impact)
The opportunity to carry out this research will allow the further development of skills and ideas in asymmetric synthesis and organic synthesis in general. The research team at RWTH can provide the facilities and the experience needed to achieve high standards in training. Links with industry / industrial relevance (22)
Not Applicable
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry aldehydes
- natural sciences chemical sciences organic chemistry organic reactions
- natural sciences chemical sciences organic chemistry ketones
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
52074 AACHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.