Objective
Research objectives and content
Tissue polarity is a fundamental property of cells. In adult cuticle of Drosophila melanogaster, polarised structures, such as bristles and hairs point posteriorly on the thorax and abdomen. The molecular basis of tissue polarity has hardly been studied and any progress in understanding will have considerable scientific impact. Experiments in Drosophila have supported earlier suggestions that tissue polarity might orient in response to a vector of a gradient of a diffusible morphogen. In spite of recent efforts to identify new tissue polarity genes, the nature of the polarity signal has remain elusive. The eye allows a new approach to this problem. I plan to study the mechanisms of cellular polarity by (i) systematically identifying genes whose products are essential for the specification of polarity in the dorsal and ventral haves of the eye and (ii) characterising the products of these candidate loci. The devised strategy to identify these genes allows the rapid scoring of a polarity phenotype in live flies. The method includes the use of silencer-trap lines that label the position of the equator in the adult eye of the living fly. Mutations will be selected by their ability to alter the expression and position of the equatorial lines in living flies.
Training content (objective, benefit and expected impact)
My primary goal is to identify new genes responsible for polarity as well as to discover any roles of known genes in polarity. I also hope to learn new methods of developmental genetics and molecular biology that will enable me to tackle any issue in developmental genetics in my future research work.
Links with industry / industrial relevance (22) The project will have no direct link with industry, but any progress in understanding of tissue polarity will have considerable scientific impact. The identification of new polarity genes would in the long run be likely to have applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 2QH Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.