Objective
Research objectives and content
Cell-cell interactions are crucial to patterning and cell differentiation in vertebrate embryos. The Eph-related family of membrane-bound receptor tyrosine kinases and their cognate ligands are among candidates for mediating such cell-cell communication. Expression studies and functional analyses have demonstrated a pivotal role for the Eph signalling during the development and patterning of the central nervous system and spinal cord. The complementarity of receptors and ligands expression patterns in different regions of the embryo together with functional studies, have led to the proposal that Eph signalling acts in establishing boundaries between regions, through mechanisms of repulsion. It is likely that Eph signalling in different morphogenetic processes leads to a common set of cellular responses including control of the cytoskeleton. The aim of the proposed research is to study the functions of the Eph signalling system in mesoderm regionalisation during zebrafish embryogenesis. I aim to analyse whether Eph receptor-ligand mediated repulsion is also used by non-neuronal cells to establish boundaries, such as between the notochord and paraxial mesoderm cells, during primary axis formation. Emphasis will be given in investigating the roles of Eph signalling in mediating cell shape and cell movement changes which occur during convergence and extension movements driving notochord morphogenesis in the zebrafish embryo.
Training content (objective, benefit and expected impact)
The proposed research will enable me to continue and expand my interest in molecular mechanisms of pattern formation in vertebrates. Most importantly, it gives me the opportunity to acquire knowledge in zebrafish embryology and genetics as well as in new techniques of cell biology. Altogether, this research experience combined with my previous knowledge of mouse genetics, would be extremely beneficial for my future scientific career in Greece. Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics
- natural sciences biological sciences cell biology
- natural sciences biological sciences developmental biology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.