Objective
Research objectives and content
The endocytic and secretory pathways of eukaryotic cells consist of various specialised membrane-bounc compartments. Vesicular transport between these compartments is fundamental to the organisation and function of: intracellular traffic routes. This process involves specific interactions between vesicles and target membranes which ensure that only appropriate fusion events occur. These interactions are thought to be regulated in part by integral membrane proteins on vesicles and target organelles, named v-SNAREs and t-SNAREs, respectively. The discovery of a novel t-SNARE on an early endosomal compartment in yeast allows us to investigate the recycling of proteins from the endocytic to the secretory pathway. The genetic and biochemical studies described in this proposal offer a unique opportunity to identify the components needed for recycling of proteins to the Golgi apparatus and cell surface, and for targeting of late secretory vesicles to particular sites of the plasma membrane The proposed studies should lead to a better understanding of how eukaryotic cells maintain their compartmental organisation.
Training content (objective, benefit and expected impact)
The requested training should deepen my insight into the organisation of the intracellular membrane system, and the traffic routes between organelles. The host institution offers me a unique chance to broaden my research skill in this field, learn yeast genetics, and gain training in a broad variety of innovative techniques.
Links with industry / industrial relevance (22)
No links with industry / no industrial relevance
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 2QH Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.