Objective
Research objectives and content The project describes an innovative and general approach to the synthesis of conformationally restricted mimetics of b-turns in biologically active peptides and proteins. The approach will be applied to the peptides hormones vasopressin, oxytocin and LHRH which are used as drugs. The pharmacodynamic and pharmacokinetic properties of the resulting hormone analogues will be evaluated in collaboration with FERRING Pharmaceuticals in Malmoe Sweden. It is expected that the analogues will display increased stability on oral administration, resulting in prolonged duration, and that information on the biologically active conformation of the hormones will be obtained. Training content (objective, benefit and expected impact) The project will widen my knowledge in synthetic organic chemistry, especially in synthesis of peptides, and also give me insight into very modern techniques like combinatorial chemistry, molecular modelling and conformational studies of peptides and peptidomimetics. All these techniques are of great interest and relevance for my planned career in chemical industry. In Addition, I will learn a new language (Swedish) and will widen my knowledge in English by permanent training. Links with industry / industrial relevance (22) The pharmacological properties of the synthetic peptidomimetics to be prepared in this project will be evaluated in collabo- ration with FERRING Pharmaceuticals in Malmoe Sweden. FERRING's main products are analogues of the hormones vasopressin and oxytocin which are used in treatment of diabetis insipidus and premature labour, respectively. In addition, the group is collaborating with PHARMACIA Immunology/Oncology in Lund in combinatorial chemistry and with scientists at ASTRA DRACO in Lund concerning synthesis of glycopeptides.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
901 87 Umeå
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.