Objective
Research objectives and content
The investigations I have carried out during the past years have contributed to the identification of mitochondria with organelles participating actively to the intracellular Ca2+ signaling network' 2. The present proposal is based on my current results which indicate that mitochondria can store and retrieve Ca2+ signals in a time-resolved manner, i.e. that mitochondria memorize the chronology of Ca signals'. Briefly, Ca is released from the organelle in a temporally-ordered rnanner that mirrors the chronology of mitochondrial Ca2 uptake, cations accumulated first being released last. My experiments show that such memory persists for minutes, indicating that mitochondrial Ca2+ is sorted and stored on a temporal basis, within an organized submitochondrial compartment. I found that most of the Ca2 taken up/released by mitochondria, is directly channeled to/from this submitochondrial compartment capable of chronological Ca2+ storage. Such unprecedented observation of a memory process at the organelle level is challenging, and incitates to the precise identification of its context of operation, its mechanisms, and its biological meaning.1- Jouaville, L.S. Ichas, F., Holmuhamedov, E.L. Camacho, P., and Lechleiter, J.D. (1995) Nature 377,348441. 2- Ichas, F., Jouaville, L.S. and Mazat, J.-P. (1997) Cell89,1145-1153. 3-lchas, F., and Bernardi, P. (1997) Nature submitted. Training content (objective. benefit and expected impact)
The proposal involves a French citizen as mobile resarcher and an Italian host institution. It is aimed both at providing advanced training to the applicant, and pursuing a new collaboration between two European groups. The research project was designed by the applicant, taking into account the specific scientific and technical environment developed by Pr. Paolo Bernardi at the host institution. The field of the project is competitive, fast moving, and the experiments proposed should provide results also of interest to researchers outside the field.
Links with industry / industrial relevance (22)
Not applicable
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
35121 Padova
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.