Objective
Research objectives and content
Active oxygen species play an important role in a large number of human conditions caused by oxygen toxicity. In this project, the question of whether superoxide anion, generated as a result of radical induced DNA damage involving the C-1' position, is capable of inducing further damage within the lipophilic environment of the DNA grooves will be examined. We will utilize synthetic modified nucleosides and oligonucleotides, able to generate superoxide anion, and we will study their reactions under physiological conditions.
Training content (objective, benefit and expected impact)
The training benefit of the previous category 30 grant can be transferred to the host institution and I will gain from the expertise of the host laboratory in the area of active oxygen species. The expected results will lead to a better understanding of the oxidative DNA damage mechanisms. The new modified nucleosides will benefit the chemistry of nucleosides and may provide new leads for the pharmaceutical industry.
Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
71409 Heraklion
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.