Objective
Research objectives and content
The phenomenon of antibiotic resistance in pathogenic bacteria is a serious threat to human health. The antibiotic of last resort is the glycopeptid vancomycin. However, a current rise of vancomycin resistant enterococci (VRE) is observed. This is alarming since there is no drug that can effectively treat a VRE infection. Dimerisation of this antibiotic plays an important role in its antibiotic action, which is promoted by binding to cell wall analogues as di-N-Ac-Lys-D-Ala-D-Ala. Furthermore the introduction of a membrane anchor increases the antibiotic activity. Binding between model systems carrying an D-alanyl-D-lactate residue shall be investigated by NMR techniques and UV difference spectroscopy. A comparison with other cell wall analogues with known binding constants will help to optimise lead structures. As a whole the results will provide substantial information about the mode of antibiotic activity. Training content
The project will allow to improve the fellow's knowledge about peptide chemistry and NMR-spectroscopic analysis of these compounds. We hope to be able to find ways to overcome the phenomenon of antibiotic resistance by development of new lead structures in antibiotic research.
Links with industry
Any lead structure would be further developed and merchandised by the European pharmaceutical industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1EW Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.