Objective
Research objectives and content
Ihe aim of the project is to compare the in vitro development of cattle embryos co-cultured on oviduct and bterine epithelial cells, obtained by using a new cell culture technique, in which they maintain their polarised epithelial character and separate the apical and the basal compartments. First the polarised cell layers will be assessed with regard to functional markers, including morphology, gene expression, energy metabolism and ion transport. Second the effect of supplementing the basal medium with hormones, resembling the changes during the oestrus cycle, will be investigated. These polarised oviduct and uterine ce11 layers, reflecting the physiological situation in vivo, will then be used in a co-culture system for cattle in vitro fertilised (IVF) embryos. Embryo development will be assessed as blastocyst formation rate, cell number and by non-invasive biochemical measurement methods. We wish to establish a new in vitro culture system for IVF cattle embryos to extend our understanding of preimplantation cattle embryos and promote physiological embryo development.
Trainining content (objective, benefit and expected impact)
In the host institution I will be trained in special techniques, e.g. electrophysiological and metabolic measurement methods and non-invasive biochemical assessment of preimplantation embryos. The project is a continuation of my recent research and will complete my dissertation to reach the qualification 'PhD'.
Linlks with industry / industrial relevance (22)
The host institution is connected with the company 'Genus' and my home institution is collaborating with tbe 'BFZF' (Bavarian Research Center of Reproductive Biology), which are both active in the in vitro production of cattle embryos.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine gynaecology reproductive medicine
- agricultural sciences animal and dairy science domestic animals animal husbandry
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences reproductive biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
YORK
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.