Objective
Research objectives and content
The approach towards drug discovery has recently made a change in paradigm as pharmaceutical companies have turned their attention to a purely statistical discovery based on high-throughput screening. Furthermore, to increase the arsenal of chemical entities for screening, chemists have started to develop combinatorial chemistry. The whole process, although remarkably successful, lacks an insight into the structure-activity relationship and advances only in a trial and error manner. We propose to develop methods improving the process by the rational use of the structural information. We will subject the initial hits identified by screening to a detailed conformational analysis. The spatial arrangement of the functional groups a their significance for the interaction with the target receptor will be analysed. The derived information will serve for design of a purpose-made combinatorial library for screening. The structure of the most active members of the library will determined and the derived information fed back to the development procedure. Structural biology will thus guide the screening towards the active molecules by mapping the conformational space accessible to the ligands in the target receptor.
Training content (objective, benefit and expected impact)
The fellowship will enable the trainee to get acquainted with the methods of modern pharmaceutical research and understand the links of the results of basic science with its industrial application. It will provide him instruction in structural biologic methods, access to the most advanced equipment and insight into the process of initial stages of drug discovery. Principal objective is to develop methodologies leading to understanding the molecular mode of action of newly discover pharmaceutically active compounds and to exploit the derived information for conception of improved molecules with desired activities.
Links with industry / industrial relevance (22)
The whole research will be carried in an industrial institute. The developed method will be applicable to many pharmacologically important systems and will be used by the host institution for discovery of new, pharmacologically active molecules and their development into drugs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences molecular biology structural biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
67080 Strasbourg
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.