Objective
Research objectives and content
Many adults and especially children with AIDS suffer from AIDS Dementia due to the HIV replication in brain tissue. Interestingly, neurons, the primary cell responsible for memory and motor functions, are not infected by the virus. In contrast, immune cells called macrophages and microglia are the principal target cells for virus. It is known that brain macrophages, when immune activated produce factors that damage neurons. In order to understand the way neurotoxins are manufactured during virus infection, we will develop an experimental system that consists of cocultures between HIV-1-infected macrophages and neurons that allow quantitative studies on the outgrowth of neurites. Since the characteristics of outgrowth of neurites affect neuronal development and survival, this model can be used to evaluate the reversible effect of therapeutic treatment of neuronal injury mediated by HIV-infected macrophages. Therefore, we wish to evaluate the efficacy of two groups of compounds that either protects neurons from injury and death or prevents the detrimental effects of neurotoxin production by HIV-infected brain macrophages in order to develop therapeutic strategies for this HIV-associated neurological disease.
Training content (objective, benefit and expected impact)
The main objective of this proposal is the development of unique in-vitro models. That will require great knowledge in cell culture techniques, monocyte isolation, PCR and ELISA The drug trials are a challenge because the drug quantities are not yet defined and have to be studied and tested. The goal is to find drugs that can prevent neuronal injury and that are suitable for in-vivo testing and maybe, in the future, some new drug can be produced for
Links with industry / industrial relevance (22)
This project can be inserted into the 'Viral Diseases' Research-Industry Task Force. It is a long-term goal of us that, in the . future, industry involvement in this project can take place and commercialisation of a new drug against HIV neuropathogenic effects can be a reality.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine neurology dementia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3584 CX Utrecht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.