Objective
Research objectives and content
Malignant cell growth results from defects in regulation of cell proliferation, differentiation and/or apoptosis. Obviously, such regulatory mechanisms provide potential therapeutic targets of prime importance. Nuclear receptor ligands, in particular steroid (antiestrogens and antiandrogens in breast and prostate cancers, respectively) and retinoid (APL, oral, and head and neck cancers, cervix carcinoma, etc.) receptor ligands are frequently; used in cancer therapy and prevention. These ligands are known to modulate cell proliferation, differentiation and/or apoptosis. However, the way how these ligands trigger regulatory events, by which nuclear receptors control the activities of these key players are largely unknown. This study is focused on the retinoid receptor system. The applicant plans to (i) investigate whether the transcriptional rates of known regulators of cell cycle and apoptosis are controlled through retinoids; (ii) identify novel genes implicated, whose transcription rates are directly regulated through retinoids; (iii) perforrn promotor analysis to reveal direct and indirect regulated events - and finally, (iv) test the cellular specificity of a panel of synthetic retinoids with respect to their activity to induce apoptosis and/or inhibition of cell proliferation, eventually in a tumor-selective fashion. Such insight in molecular mechanisms of signal transduction will pave the way towards novel strategies for therapeutic intervention in cancer.
Training content (objective, benefit and expected impact)
This research project covers training in sophisticated methods to study transcription regulation of cell progression and apoptosis by retinoic acids. A broad spectrum of methodologies will be covered, linking nucleic acid- and protein-based approaches. Experience available at the host institute regarding cell culture and analyzing transcriptional events allow to design direct approaches and learn the required methodology from experienced personnel. Finally this research will help to further intensify skills to study protein/DNA and protein/protein interaction. Overall, this programme will provide the applicant with a highly advanced experience and allow him to perform independent research at his home country. The IGBMC is an institute of high reputation, it offers a forum to meet distinguished scientits and is a top choice for advanced training.
Links with industry / industrial relevance (22)
The group of Dr. Hinrich Gronemeyer has established through various projects (Bl02-CT93-0473; BMH4CT96- 0181) solid contacts with both Schering AB, Berlin, and Roussel-UCLAF, Paris. A long tradition of links to scientific groups working on basic research and clinical aspects of cancer (within the institute as well as at the Universities of Strasbourg and Paris) will enhance the scientific significance and promote the exchange of ideas for research conducted at the IGBMC.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology head and neck cancer
- medical and health sciences clinical medicine oncology cervical cancer
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
67404 ILLKIRCH GRAFFENSTADEN
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.