Objective
Research objectives and content
A consortium of Japanese and European labs has recently completed sequencing the genome of Bacillus subtilis-168. Some European labs undertake now a project to systematically inactivate and determine the function of new genes of the sequence. The object of this project would be to contribute to the screening of the mutants showing defects in sporulation and cell division.Then one or more of the identified mutants of interest would be studied in detail:1. Analysis of the phenotype at the cellular and sub-cellular level, 2. Regulation and expression of the gene, 3. Sub-cellular localization of the protein product, 4. Purification of the protein and investigation of its enzymatic properties and interaction with other proteins.Further development of the project would depend upon the nature of the gene itself and to what extent its study can be integrated with other work ongoing in the lab. Training content (objective, benefit and expected impact)
At Oxford, the expertise of the lab ln sporulation, cell division and chromosome partitioning would be used to look specifically for defects in these functions. I would benefit of a wide range of useful methods, especially in molecular genetics, biochemistry and state-of-the-art cytological methods, which are well established in this lab. Links with industry / industrial relevance (22)
There is considerable commercial interest in this area at the moment, in relation to development of new antibiotics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences molecular biology molecular genetics
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 3RE OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.