Objective
Research objectives and content
The research group of Prof. Nolte (University of Nijmegen) is one of the few that has developed model systems for Cytochrome P-450, enzyme that catalyze a variety of oxidation reactions (hydroxilation of alkanes, epoxidation of alkenes...). There is great interest in the development of these catalytic systems not only to understand the natural enzyme systems but also to develop a new generation of synthetic catalysts. These systems contain all the key features of the natural enzyme with the only drawnback that it does not exhibit substantial substrate selectivity. The objective of this project is to construct an oxidative catalytic system which exhibit substrate selectivity and ultimately enantioselectivity. The research will consists of several phases: 1 ) The
synthesis of the manganese porphyin, the rhodium-bipyridine reductor, and amphiphilic molecular baskets. 2) Assembly and study of vesicles containing all three of the above components. 3) Investigation of the catalytic behaviour and substrate selectivity of the new model system. Subsequent optimization of the catalytic propertis by modification the receptor, surfactant and the reductor. 4) The inclusion of chirality in the working model, (by the use of chiral surfactants, chiral porphyrin catalytic sites and chiral receptors and the study of enantioselective properties of such systems).
Training content (objective, benefit and expected impact)
The proposed training will significantly enhance my knowlegde in the areas of synthesis, catalysis and the developing research field of nanosized functional devices. Catalysts by definition are of great social and industrial importance, in particular oxidative catalyst which use environmentally friendly moleculer oxygen. If the potential of this system if fully realized then this will be one of the first functional supramolecular self-assembling selective enzyme mimics.
Links with industry / industrial relevance (22)
The group has extensive experience in the investigation of oxidation catalyts and has currently an industrial collaboration with DSM studying the oxidative catalysis of alkene-aromatic molecules using molecular oxygen.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6500 GL Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.