Objective
Research objectives and content The project consists of the synthesis of patellin 2 and trunkamide A, two cyclopeptides of marine origin, on a gram scale for the completion of medical trials. These products have not, as yet, been synthesised and are thus only available on a limited scale from natural sources. Patellin 2 and trunkamide A share a common cyclopeptide motif based upon natural rigid aminoacids, such as proline and thiazoline, and feature two unusual serine or threonine derivatives with reverse prenyl group side-chains. A solid phase approach is planned for the linear peptide, followed by either cylisation and then thioazline formation, or initial construction of the thiazoline motif followed by cyclisation. The synthesis of an aminothioacid is also required. Training content (objective, benefit and expected impact) This project will involve several areas of chemistry such as organometallic, organic and peptide synthesis, wich have become of increasing interest in both pharmaceutical and combinatorial chemistry providing ideal training for an academic position in this area (for which post-doctoral experience is essential) but also offering an attractive opportunities for an industrial career Links with industry / industrial relevance (22) Two Spanish companies, Pharma Mar (a world leader in marine source metabolites) and LIPOTEC, are strongly interested in the synthesis of patellin 2 and trunkamide A, since this will allow them to complete characterisation and therapeutic studies, focusing particularly on the fight against cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08028 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.