Objective
Research objectives and content Calcium is the primary mediator of electrical-dependent gene expression in neurons. It acts in two cell compartments, the nucleus and the cytoplasm, stimulating distinct mechanisms of transcriptional cont The transcription factor CRE binding protein CREB and its coactivator CREB binding protein CBP, which is recruited to the promoter by CREB phosphorylation on serine 133, are important mediators of calcium- regulated gene expression. The aim of this project is to investigate the role of CBP in calcium-induced transcription. I will identify calcium-regulated transcriptional activation domains of CBP and determine the role calcium/calmodulin dependent (CaM) protein kineses and MAP kineses, that are activated by increased intracellular calcium concentrations, in the control of their activity. Furthermore, I will analyse phosphorylation of CBP following activation of calcium signalling pathways and I will determine the role' putative phosphorylation sites in the control of CBP activity. Training content (objective, benefit and expected impact) The proposed project will allow me to acquire knowledge and expertise in calcium signalling. I will of training in studying mechanisms controlling gene expression and learn new up-to-date techniques whichwill greatly improve my scientific skills. This will, in the future, allow me to carry out independent research in molecular neuroscience. Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences molecular biology molecular neuroscience
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 2QH Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.