Objective
Research objectives and content T lymphocytes can differentiate in the thymus from common precursor cells, into one of two phenotypically distinct lineages, called CD4+ or CD8+ T cells. The signals which dictate which of the two lineages a precursor will mature into are not well understood. In the lab, they have developed an experimental system using mono- and bi-specific F(ab')2 antibody fragments which can be used to alter the fate of developing thymocytes in foetal thymus organ cultures, and cause them to mature specifically into either the CD4 or CD8 lineage. In this proposal I plan to investigate the biochemical basis of this differential signalling in order to gain a greater understanding of how these lineage commitment decisions are made. I shall examine the activation of intracellular signaling molecules downstream of the cell surface receptors using a variety of techniques, including examination of tyrosine phosphorylation and tyrosine kinase activity of molecules which have been previously described as important in T cell signalling. This investigation will promote our understanding of the signals responsible for directing differentiation of cells of the immune system. Training content (objective, benefit and expected impact) The research proposal involves using a variety of techniques including immunology, protein biochemistry and molecular biology, some of which I have experience with, but many will be new to me. The lab has experienced post-docs and technical staff who will train me in techniques that are new, which will greatly enhance my overall practical expertise. In addition the department has an active research seminars and journal club program which will expose me to current ideas and state of the art information in immunology. Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
NW7 1AA London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.