Objective
Research objectives and content Integrins are a family of cell surface receptors, which mediate adhesion of cells to the extracellular matrix. The binding of integrins to extracellular matrix also triggers interacellular signalling pathways that are important for cellular differentiation. The goal of the proposed research is to initiate a characterisation of an integrin signalling pathway in Drosophila, by analysing the function of components at the top and bottom of the pathway: 1) Integrin-linked-kinase, is a kinase that directly associates with integrin cytoplasmic domains, and a Drosophila homologue has emerged from the genome sequencing project. The function of this protein during development will be analysed using molecular and genetic approaches. 2) A gene has recently been identified in Drosophila that is subject to regulation by an integrin signalling pathway. The cis-regulatory regions of this target gene will be characterised to clarify how integrin signalling modulates its expression. Training content (objective, benefit and expected impact) This project will provide excellent training in molecular biological techniques and basic genetics. In the future I plan to apply these techniques to insects with medical and economic importance. Links with industry / industrial relevance (22) This research is not currently linked to an industrial partner. However, the integrins are of great interest to the pharmaceutical industry, so links in the future are feasible.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences zoology entomology
- natural sciences biological sciences genetics genomes
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Coordinator
CB2 1QR Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.