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Combinatorial approaches to molecular catalysts

Objective



Efficient and selective organic molecular catalysts could make important contributions to the future of the European chemical industry; make major contributions in several areas of industrial importance (notably the discovery of pharmaceuticals). The training provided in these facilitating the synthesis of complex molecules with maximum economy and minimal environmental impact. The proposers wish to apply the new techniques will be of great future benefit to the European chemical community techniques of "combinatorial chemistry" to the development of such catalysts.

They have adopted a generalised design consisting of a scaffold with several attached side-chains, able to act cooperatively on a centrally-located substrate. The scaffold will be immobilised on a polymer support, and the side chains elaborated to yield libraries of structures with potential catalytic properties. Smaller libraries will be tested directly for the desired activity, while larger ones will be "pre-screened" through assessment of binding to transition state analogues. The Network will develop the methodology initially in the context of four sub-programmes, employing complementary technologies and targetted athydrolytic and carbon-carbon bond forming processes. Components for the work will be produced by all eight laboratories and made available throughout the Network.

Funding Scheme

NET - Research network contracts

Coordinator

Philipps-Universität Marburg
Address
Hans Meerwein Straße
35043 Marburg
Germany

Participants (9)

GENT UNIVERSITY
Belgium
Address
653,Coupure Links 653
9000 Gent
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Ireland
Address
Belfield
4 Dublin
THE UNIVERSITY OF MILANO
Italy
Address
Via Venezian 21
20133 Milano
UNIVERSITAT DE BARCELONA
Spain
Address
11,C/ Martí I Franquès 1
08028 Barcelona
UNIVERSITY OF BRISTOL
United Kingdom
Address
Cantock's Close
BS8 1TS Bristol, Clifton
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Address
Kensington Terrace 6 Bedson Building
NE1 7RU Newcastle Upon Tyne
UNIVERSITY OF SHEFFIELD
United Kingdom
Address
Brook Hill
S3 7HF Sheffield
University of Cambridge
United Kingdom
Address
Lensfield Road
CB2 1EW Cambridge
Université de Paris XI (Université Paris-Sud)
France
Address
5 Rue Jean Baptiste Clément
92296 Châtenay-malabry