Objective
Young postdoctoral researchers will be given the opportunity to apply all countries, cooperating to study the intriguing, but elusive mechanism of the available techniques to the particular protein, or class of proteins, protein folding. Two of the groups have a strong background in that was assigned to them. We foresee that at least some of these trainees computational biophysics, the remaining groups are equipped to do will actually perform part of their research in other laboratories within experimental work on various proteins. The combined expertise includes the network. They will be trained, not only to apply these techniques, but also to cooperate closely with theoreticians, working on the same protein, important techniques like NMR and mass spectrometry, as well as stopped flow spectroscopy, calorimetry, and molecular biology, peptide synthesis to formulate testable models of protein folding and to perform protein engineering. From the theoretical point of view we envisage an evaluate such tests. On the other hand, theoreticians will be trained in important role for molecular dynamics calculations in combination with the producing testable models wherever possible, and to accommodate the results essential dynamics analysis.
of such tests in an improved model. They will be encouraged to participate The primary issue will be the identification, by theoretical and in network research meetings, network discussions (possibly via the experimental means, of nucleation centres, where protein folding is Internet), as well as the regular summer schools, master classes, and initiated, and of folding intermediates, followed by their structural and international conferences.
kinetic characterisation. Where possible stable nucleation centres and folding intermediates will be prepared in isolation, by synthesis or via expression of the corresponding genes in microorganisms, for more detailed structural studies and kinetic measurements. In parallel computer models will be studied, with an emphasis on the correct modelling of solvent/solute interactions, in order to formulate testable hypotheses of the sequence of events in protein folding and the nature of nucleation centres and folding intermediates.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins protein folding
- natural sciences chemical sciences analytical chemistry calorimetry
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences physical sciences optics spectroscopy
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9747 AG GRONINGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.