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INSECT-PARASITE interactions : MOLECULAR ASPECTS of INFECTION AND IMMUNITY in DIPTERA

Objective



Transmission of the malaria parasite (genus Plasm odium) from one questions in parasitology, vector biology and invertebrate immunity, vertebrate host to another requires successful infection of a mosquito thereby bridging these disciplines. Training will consist of benchwork, vector, during the course of which the parasite undergoes complex attendance at research seminars, reading and discussion of the relevant differentiation and growth processes in association with diverse insect literature. Results will be presented at regular laboratory meetings as tissues. Interactions between parasite-encoded proteins and host molecules can critically influence Plasmodium viability and differentiation and well as inter-laboratory meetings involving members of the network. Young research fellows will conduct research in different network laboratories therefore the capacity of the vector to transmit malaria. The objectives as appropriate. In addition network members will attend specialised of the proposed research are to identify novel Plasmodium and Anopheles courses and international conferences.
mosquito gene products which interact to facilitate tissue invasion, or play a role in host defence responses elicited by immune-recognition of parasite determinants. Stage-specific parasite genes which may affect viability within, or invasion of, specific host tissues will be isolated as well. Very little is known at the molecular level of mechanisms of Plasmodium parasite invasion and survival in mosquitoes. Basic information regarding these phenomena are needed for the initial development and refinement of malaria control strategies targeted towards interruption of disease transmission at the level of the vector.

Funding Scheme

NET - Research network contracts

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Address
1,Meyerhofstraße 1
69117 Heidelberg
Germany

Participants (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
15,Rue Rene Descartes 15
67084 Strasbourg
FOUNDATION OF RESEARCH AND TECHNOLOGY - HELLAS
Greece
Address
Vassilika Vouton
71110 Iraklion
Imperial College of Science Technology and Medicine
United Kingdom
Address
Prince Consort Road
SW7 2BB London
Imperial College of Science Technology and Medicine
United Kingdom
Address
Prince Consort Road
SW7 2BB London
Università degli Studi di Roma La Sapienza
Italy
Address
Piazzale Aldo Moro 5
00185 Roma