The instigation of a multidisciplinary approach to the analysis of cellular controlled genetic programmes that are regulated by extracellular stimuli. signalling mechanisms merges biophysical, cell biological, molecular biological, and genetic techniques towards a common goal. This integrated These stimuli activate intracellular cascades which transduce signals to approach to solving an important cellular signalling problem will provide the nuclei and modulate transcription factor function and gene activity. a broad and expert knowledge base that will teach young scientists an These cascades are wired into very complex interconnected networks of extensive range of different techniques in modern biology in a signalling pathways and are largely driven by second messenger systems and by the enzymatic activities of protein kinases and protein phosphatases. goal-oriented manner.
Misregulation of signalling networks is a major cause of cell malfunction and disease. .
We propose to set up a TMR network that will instigate a coordinated multidisciplinary dissection of the complex signalling pathways that regulate gene activity during cell proliferation and differentiation. We will use:
(i) biochemical techniques to analyse enzymatic reactions in signal transduction,
(ii) biophysical methods to determine the molecular structures of the signal targets,
(iii) genetic approaches in Drosophila melanogaster, Mus musculus, and Saccharomyces cerevisiae to provide novel insights into signal cascades and
(iv) molecular studies to understand signal-dependent gene control.
Funding SchemeNET - Research network contracts
67404 Illkirch Graffenstaden
DD1 4HN Dundee