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SIGNALLING NETWORKS in DEVELOPMENT AND DISEASE

Objective



The instigation of a multidisciplinary approach to the analysis of cellular controlled genetic programmes that are regulated by extracellular stimuli. signalling mechanisms merges biophysical, cell biological, molecular biological, and genetic techniques towards a common goal. This integrated These stimuli activate intracellular cascades which transduce signals to approach to solving an important cellular signalling problem will provide the nuclei and modulate transcription factor function and gene activity. a broad and expert knowledge base that will teach young scientists an These cascades are wired into very complex interconnected networks of extensive range of different techniques in modern biology in a signalling pathways and are largely driven by second messenger systems and by the enzymatic activities of protein kinases and protein phosphatases. goal-oriented manner.
Misregulation of signalling networks is a major cause of cell malfunction and disease. .
We propose to set up a TMR network that will instigate a coordinated multidisciplinary dissection of the complex signalling pathways that regulate gene activity during cell proliferation and differentiation. We will use:
(i) biochemical techniques to analyse enzymatic reactions in signal transduction,
(ii) biophysical methods to determine the molecular structures of the signal targets,
(iii) genetic approaches in Drosophila melanogaster, Mus musculus, and Saccharomyces cerevisiae to provide novel insights into signal cascades and
(iv) molecular studies to understand signal-dependent gene control.

Funding Scheme

NET - Research network contracts

Coordinator

Medizinische Hochschule Hannover
Address
Carl-neuberg-strasse 1
30623 Hannover
Germany

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Eberhard-Karls-Universität Tübingen
Germany
Address
7,Wilhelmstrasse
72074 Tübingen
Eidgenössische Technische Hochschule - ETH Zürich
Switzerland
Address
Höneggerberg
8093 Zürich
FOUNDATION OF RESEARCH AND TECHNOLOGY - HELLAS
Greece
Address
Vassilika Vouton
71110 Iraklion
NATIONAL HELLENIC RESEARCH FOUNDATION
Greece
Address
48,Vas. Constantinou Avenue 48
11635 Athens
Stiftung Max-Delbrück-Centrum für Molekulare Medizin
Germany
Address
10,Robert-rössle-straße
13125 Berlin
UNIVERSITY OF ZURICH
Switzerland
Address
190,Winterthurstrasse 190
8057 Zurich
University of Dundee
United Kingdom
Address
Nethergate
DD1 4HN Dundee
Universität Wien
Austria
Address
9,Dr Bohrgasse
1030 Wien