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Mammalian mrna poly(a) tails, formation removal and function

Objective



We propose to establish a network of collaborating research teams having the mRNA poly (A) tail as a common scientific denominator. All mamalian mRNAs have at 3' ends a 200 residues long poly (A) tail. The poly (A) tail is added post-transcriptionally (nuclear
polyadenylation) and this reaction is used by all type of cells to regulate gene expression. In some cells the lengh of the poly (A) tail is metabolised, either by removal or by readdition. Modulating the length of the poly (A) tail regulates translational capacity of an mRNA. Research within this network will increase knowledge in: 1) biochemical details of nuclear polyadenylation.
2) regulation of gene expression through poly (A) site selection 3) functional importance of poly (A) tail metabolism.
We propose to establish an advanced "school" for training of young post-doctoral fellows. After completion of the three year programme participating fellows should be able to establish independent research programs in their home countries. The young scientists will receive training in:
1) theoretical, experimental and methodological scientific
approaches.
2) organisation and execution of advanced practical and theoretical courses/workshops.
3) interaction and communication with other scientists.

Funding Scheme

NET - Research network contracts

Coordinator

Uppsala University
Address
3,Husargatan
751 23 Uppsala
Sweden

Participants (7)

Centre Médical Universitaire
Switzerland
Address
1,Rue Michel Servet
1211 Genève
JUSTUS-LIEBIG-UNIVERSITY OF GIESSEN
Germany
Address
58,Sriedrichstr. 24
35392 Giessen
Martin-Luther-Universitat Halle-Wittenberg
Germany
Address
16 A,weinbergweg 16 A
6120 Halle
Regional Anticancer-Oncology Hospitalof Athens "Saint Saves"
Greece
Address
171,Alexander Avenue
115 22 Athens
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
South Parks Road
OX1 3RE Oxford
University of Glasgow
United Kingdom
Address
Church Street
G11 5JR Glasgow
Universität Basel
Switzerland
Address
70,Klingelbergstraße
4056 Basel