Skip to main content
Aller à la page d’accueil de la Commission européenne (s’ouvre dans une nouvelle fenêtre)
français fr
CORDIS - Résultats de la recherche de l’UE
CORDIS
Contenu archivé le 2024-05-14

Mammalian mrna poly(a) tails, formation removal and function

Objectif



We propose to establish a network of collaborating research teams having the mRNA poly (A) tail as a common scientific denominator. All mamalian mRNAs have at 3' ends a 200 residues long poly (A) tail. The poly (A) tail is added post-transcriptionally (nuclear
polyadenylation) and this reaction is used by all type of cells to regulate gene expression. In some cells the lengh of the poly (A) tail is metabolised, either by removal or by readdition. Modulating the length of the poly (A) tail regulates translational capacity of an mRNA. Research within this network will increase knowledge in: 1) biochemical details of nuclear polyadenylation.
2) regulation of gene expression through poly (A) site selection 3) functional importance of poly (A) tail metabolism.
We propose to establish an advanced "school" for training of young post-doctoral fellows. After completion of the three year programme participating fellows should be able to establish independent research programs in their home countries. The young scientists will receive training in:
1) theoretical, experimental and methodological scientific
approaches.
2) organisation and execution of advanced practical and theoretical courses/workshops.
3) interaction and communication with other scientists.

Champ scientifique (EuroSciVoc)

Ce projet n'a pas encore été classé par EuroSciVoc.
Proposez les domaines scientifiques qui vous semblent les plus pertinents et aidez-nous à améliorer notre service de classification.

Programme(s)

Thème(s)

Appel à propositions

Données non disponibles

Régime de financement

NET - Research network contracts

Coordinateur

Uppsala University
Contribution de l’UE
Aucune donnée
Adresse
3,Husargatan
751 23 Uppsala
Suède
Coût total
Aucune donnée

Participants (7)