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Towards an understanding of carbohydrate recognition in aqueous media

Objective



Synthetic skills and an understanding of intermolecular interactions are: The proposed Network aims to study the important natural process of carbohydrate recognition through investigations on synthetic model systems especially important in most areas of the chemical industry. Supramolecular chemistry is thus an excellent training ground for young researchers. The in doing so it hopes to design/discover the first truly effective synthetic biomimetic receptors for carbohydrates in aqueous media.

The research proposed Network contains laboratories with a range of specialities within programme will incorporate: (a) the rational design of macrocycles with this area. A connection with industry adds a biological dimension. Young amphiphilic cavities, closely similar to the binding sites of natural scientists within the programme will be trained through collaborative receptors; (b) the discovery of "pod and-type" receptors through research in their own and other laboratories, visits to industry, attendance at conferences and Network meetings, and presentation of their combinatorial chemistry; (c) combinatorial discovery through template down results. At least 1O will be supported through Network funding, and self-assembly under thermodynamic control; (d) physical-organic studies on many others will be involved in the programme relevant interactions; (e) studies at surfaces (where unusual effects are expected); and (f) searches for biological activity (through cooperation with industry). The work should lead to an improved understanding of carbohydrate recognition in nature, and to new ways of influencing biological systems. Possible outcomes are anti-infective agents, and new separation systems for glycosylated biomolecules.

Funding Scheme

NET - Research network contracts

Coordinator

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN
Address
Belfield
4 Dublin
Ireland

Participants (7)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
S/n,americo Vespucio S/n
41092 Sevilla
Consejo Superior de Investigaciones Cientificas
Spain
Address
3,Juan De La Cierva
28071 Madrid
Freie Universität Berlin
Germany
Address
3,Takustrasse
14195 Berlin
UNIVERSITY OF BRISTOL
United Kingdom
Address
Cantock's Close
BS8 1TS Bristol, Clifton
UNIVERSITY OF SHEFFIELD
United Kingdom
Address
Brook Hill
S3 7HF Sheffield
UNIVERSITÀ DEGLI STUDI DI PARMA
Italy
Address
Viale Delle Scienze 17/A
43100 Parma
University of Cambridge
United Kingdom
Address
Lensfield Road
CB2 1EW Cambridge