Objective Metallo-lactamases, which typically exhibit activity against a broad. Structural and mechanistic studies on enzymes are the major assets of the network and will become one of the major tools involved in the design of range of lactam antibiotics represent a new threat to oar arsenal of antimicrobial agents. The goals of the present project are to accumulate future drugs detailed knowledge on the crystal and solution structures of these enzymes intended to familiarize the young researchers with state of the art and the role of the metal ion(s) in their catalytic pathways in order to techniques in this field. giving them a deep understanding of the design and develop efficient and specific inhibitors. To attain these possibilities and limitations of each particular technique. To complete objectives, a unique integrated interdisciplinary approach will be this training, advanced courses are or will be organized by several of the teams utilized, involving, in addition to classical molecular biology and approaches followed and the problems encountered in modern drua biochemistry techniques, X-ray crystallography, Nuclear Magnetic Resonance, development mass spectrometry and spectroscopic methods dependent on the presence of metal ions in the active sites. Moreover, the role of the metal ions on the folding of the proteins and factors responsible for the stability of the only known tetrameric metallo-lactamase produced by Stenotrophomonasmaltophilia will be analysed proposal have already, thanks to a HCM Network, taken an uncontested leadership in the field. The expansion of the Network to new teams, contributing expertise in Protein NMR and Perturbed Angular Correlation Pray spectroscopy is expected to reinforce this leadership and ultimately result in the development and marketing of the designed inhibitors by an Fields of science natural sciencesearth and related environmental sciencesgeologymineralogycrystallographynatural scienceschemical sciencesanalytical chemistrymass spectrometrynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesnatural sciencesphysical sciencesopticsspectroscopynatural sciencesbiological sciencesmolecular biology Programme(s) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Topic(s) 02 - ACCESS TO LARGE-SCALE FACILITIES Call for proposal Data not available Funding Scheme NET - Research network contracts Coordinator UNIVERSITE DE LIEGE EU contribution No data Address 17,Allee de la Chimie 3 - Bètiment B6 4000 LIEGE Belgium See on map Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all Centre National de la Recherche Scientifique (CNRS) France EU contribution No data Address 17 avenue des Martyrs 38041 Grenoble See on map Total cost No data SAARLAND UNIVERSITY Germany EU contribution No data Address Im Stadtwald 151150 SAARBRUECKEN See on map Total cost No data SmithKline Beecham Pharmaceuticals Ltd. United Kingdom EU contribution No data Address Third Avenue CM19 5AD Harlow See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address South Parks Road OX1 3QT OXFORD See on map Total cost No data THE ROYAL VETERINARY AND AGRICULTURAL UNIVERSITY Denmark EU contribution No data Address 40,Thorvaldsensvej 40 1871 FREDERISKSBERG See on map Total cost No data UNIVERSIT DEGLI STUDI DI SIENA Italy EU contribution No data Address Via Bracci, 16 53100 SIENA See on map Total cost No data UNIVERSITÀ DEGLI STUDI - L'AQUILA Italy EU contribution No data Address Via Vetoio 67010 ASSERGI See on map Total cost No data University of Leicester United Kingdom EU contribution No data Address University Road LE1 9HN Leicester See on map Total cost No data