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New Technology for Cascade Combinatorial Chemistry

Objective



This project is aimed at establishing advanced generic technology for the University output of combinatorial chemists in essentially zero. The network will remedy this and provide researchers with a broad advanced synthesis of complex heterocycles based on cascade combinatorial chemistry. skill base in key technologies by ensuring multiskill acquisition in The targeted core heterocycles include a number of outstandingly valuable agrochemicals and drugs, so there are major opportunities for this generic multicomponent cascade combinatorial chemistry, catalysis, computational techniques (diversity, virtual libraries), analytical techniques, polymers technology to lead to new, more effective, agrochemicals and medicines synthesis/fabrication. There is no skill base in the agro/pharma industries thereby benefiting both European industry and quality of life. in cascade combinatorial chemistry and polymer synthesis/fabrication. All The project platform is the innovative skill base of the partners which places them at the leading edge in catalytic (Pd/Ni) cascade reactions and researchers will gain (i) experience at two academic laboratories and cascade cycloaddition reactions supported by a major agrochemical company Rhone-Poulenc (ii) high quality skills in cascade combinatorial chemistry (Rhone- Poulenc) and two interdisciplinary research centres, in Polymer and associated technologies (polymers/analytical) (iii) verbal and written presentational and problem solving skills via network seminars and work-Science and Molecular Innovation, Diversity and Automated Synthesis (MIDAS). shops.
Using a clean technology multicomponent cascade reaction approach provides a major breakthough that enables a combination of complexity and diversity to be achieved that far outstrips that available by conventional combinatorial chemistry. This innovative cascade chemistry will be allied to new linker design and polymer synthesis/fabrication followed by 10 x 10 demonstration library syntheses by the academic partners. Rhone-Poulenc will apply the new technology to larger libraries and transfer expertise/skills in computational design of virtual libraries and diversity allied to advanced analytical techniques for following polymer based reactions and assesssment of library purity.

Coordinator

UNIVERSITY OF LEEDS
Address
Woodhouse Lane
LS2 9JT Leeds
United Kingdom

Participants (4)

Georg-August-Universität Göttingen
Germany
Address
2,Tammannstrasse
37077 Göttingen
RHONE - POULENC AGRICULTURE LTD.
United Kingdom
Address
Fyfield Road
CM5 0HW Ongar
Universidad de Barcelona
Spain
Address
S/n,avinguda Joan Xxiii S/n
8028 Barcelona
Université de Lyon I (Université Claude Bernard)
France
Address
43 Boulevard Du 11 Novembre 1918
69622 Villeurbanne