Objective Allergen products used for diagnosis and treatment of allergy are based on natural, heterogeneous allergen extracts. Standardization of these complex biologicals is based on measurement of their overall IgE binding potency by skin tests and immunoassays with pooled allergic sera. Differences in composition are not revealed and the major disease related components, the major allergens, are not individually quantified. Consequently, allergen products on the market are ill defined and not directly comparable. Measurement of major allergens in mass units is the solution to this problem. The proposal aims at the development of CRMs based on recombinant or natural versions of 8 major allergens from 4 of the most important allergen sources in Europe: birch, grass and olive pollen and house dust mite. Recombinant allergens will be compared physico-chemically and immunologically with their natural counterparts. Based on this analysis, candidate CRMs will be selected. In addition, monoclonal antibody based sandwich ELISAs for their measurement will be produced and validated. Together this will improve standardization and comparability of allergen products, resulting in increased safety and efficacy. Fields of science medical and health sciencesclinical medicineallergology Programme(s) FP5-GROWTH - Programme for research technological development and demonstration on "Competitive and sustainable growth 1998-2002" Topic(s) 1.1.3.-6. - RTD Activities of a Generic Nature : Measurements and Testing Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator CLB - SANQUIN BLOOD SUPPLY FOUNDATION Address Plesmanlaan 125 1066 CX Amsterdam Netherlands See on map EU contribution € 0,00 Participants (17) Sort alphabetically Sort by EU Contribution Expand all Collapse all ALK-ABELLO AS Denmark EU contribution € 0,00 Address Boge alle 6-8 2970 Hoersholm See on map ALLERGOPHARMA JOACHIM GANZER KG Germany EU contribution € 0,00 Address Hermann koernerstrasse 52 21465 Reinbek See on map ASAC PHARMACEUTICAL INTERNATIONAL A.I.E. Spain EU contribution € 0,00 Address Sagitario 14 03006 Alicante See on map BERUFSGENOSSENSCHAFTLICHES FORSCHUNGSINSTITUT FUER ARBEITSMEDIZIN Germany EU contribution € 0,00 Address Buerkle-de-la-camp platz 1 44789 Bochum See on map BIOMAY PRODUKTIONS- UND HANDELSGESELLSCHAFT M.B.H. Austria EU contribution € 0,00 Address Universitaetstrasse 11 4020 Linz See on map CBF LETI S.A. Spain EU contribution € 0,00 Address Sol 5 28760 Tres cantos See on map HAARLEMS ALLERGENEN LABORATORIUM B.V. Netherlands EU contribution € 0,00 Address Parklaan 125 2011 KT Haarlem See on map IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 0,00 Address Norfolk place, paddington W2 1PG London See on map INDOOR BIOTECHNOLOGIES LIMITED United States EU contribution € 0,00 Address Mr-4 building - lane road VA 22908 Charlottesville See on map ISTITUTO SUPERIORE DI SANITA Italy EU contribution € 0,00 Address Viale regina elena 299 00161 Roma See on map NATIONAL BIOLOGICAL STANDARDS BOARD United Kingdom EU contribution € 0,00 Address Blanche lane, south mimms EN6 3QG Potters bar See on map PAUL-EHRLICH-INSTITUT, FEDERAL AGENCY FOR SERA AND VACCINES Germany EU contribution € 0,00 Address Paul-ehrlich-strasse 51-59 63225 Langen See on map RESEARCH CENTER BORSTEL, CENTER FOR MEDICINE AND BIOLOGICAL SCIENCE Germany EU contribution € 0,00 Address Parkallee 1-40 23845 Borstel See on map STALLERGENES SA France EU contribution € 0,00 Address Rue alexis de tocqueville 6 Antony See on map Links Website Opens in new window UNIVERSIDAD COMPLUTENSE DE MADRID Spain EU contribution € 0,00 Address Ciudad universitaria 28040 Madrid See on map UNIVERSITY OF SALZBURG Austria EU contribution € 0,00 Address Hellbrunner strasse 34 5020 Salzburg See on map UNIVERSITY OF VIENNA Austria EU contribution € 0,00 Address Waehringer guertei 18-20 1090 Wien See on map
