Objective
The major research projects done by SESMA with the European Mass Spectrometry Network included:
- Analysis of human haemoglobin variants. This technique is used to give chemical and molecular descriptions of diseases. Using this procedure, a large number of haemoglobins were characterised, including several uncommon and two completely new genetic variants.
- Characterisation of protein adducts with genotoxic xenobiotics. To help detect cancer risk with better certainty, this research aimed at gathering more and better quality information about the reactivity of genotoxic xenobiotics with proteins and peptides, using mass spectrometry.
- Post-translational modifications. The accurate determination of protein molecular weight by electrospray mass spectrometry can provide definitive data on the occurrence of post-translational events, including proteolytic processing of the polypeptide chain. In this case, the accuracy of the analysis leads to the location of the maturation site within the protein sequence.
- Recombinant protein analysis. The application of recombinant DNA methodologies greatly enhanced the need for definitive structural information on protein products obtained by genetic engineering. The most important alternative approach to classic biochemistry procedures (Edman degradation, HPLC mapping, etc) is the use of mass spectrometry methods such as ES/MS, FAB/MS and FAB/MS/MS.
This project helped form a European Network on Biomolecular Mass Spectrometry involving eight laboratories from across the EU, working in the field of biological mass spectrometry.
Funding for this project coincided with the purchase, by the National Research Council, of a ZAB-T tandem mass spectrometer allowing high sensitivity, high mass four sectors (tandem), characterised by a new geometry and designed to address the structural analysis of biomolecules in the low femtomole range. This device combines the most recent innovations in the production and detection of high mass ions, which play an increasing role in the determination of peptide and other biopolymer molecular weights.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences medical biotechnology genetic engineering
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences mathematics pure mathematics geometry
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80131 Napoli
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.