Objective
The Background The Problem: Global antibiotic resistance by bacteria is becoming an increasing public health concern, and the race is on to discover new antibacterial (Bax et al., 2000). The importance of carrying out this type of research and surveillance of antibiotic resistance is critical (reviewed by Aubry-Damon and Courvalin, 1999). In addition to the use of antibiotics, non-steroidal anti- inflammatory drugs (NSAIDs) are also used routinely to treat numerous gram-negative infections. However, there are increasing concerns over complications caused by NSAIDS in infections an in this field, nez therapeutics are also in demand. Therefore, the aim of this investigation was to;
- Determination and comparison of the anti-microbial actins of Aloe vera Barbadensis Miller with ampicilllin and nalidixic acid (routine antibiotics for the treatment of shigellosis). This was achieved by investigating the minimum inhibitory concentrations of Aloe Vera needed to kill Shigella Flexneri.
- Determination and comparison of the anti-inflammatory actions of Aloe vera Barbadensis Miller with a known NSAID (Ibuprofen).
This was achieved by investigating TNF-alfa and IL-1Beta release by blood cells incubated with Shigella flexneri. These results were similar to those obtained by Shelton (1991) who showed that Aloe Vera had anti-microbial properties in vitro and inhibited Mycobacterium tuberculosis and Bacillus subtilis. S.flexneri has been shown to be completely resistant to ampicillin at concentrations greater than 256 µg/ml (Navia et al., 1999). It is thought that antibiotic resistance in shigellosis is due to the over use of antibiotics (Travis, 1994). As with many antibiotics, nalidixic acid has many side-effects when given at this dose, including nausea, vomiting, dyspepsia, abdominal pain, diarrhoea, headache, dizziness, sleep disorders and rash (BNF, 2000. An advantage of using Aloe vera as an anti-microbial is that anecdotally, fewer side effects have been reported.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
KA7 2AX AYR
United Kingdom
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