Objective
Fungal infections are becoming a major medical problem. Life-threatening Candida, Coccidiodes, Cryptococcus, Histoplasma, and Aspergillus infections are on the increase. The most common fungal pathogen of humans, Candida albicans, causes superficial infections of mucosal epithelia, but also deep-seated infections, particular in immuno-compromised patients, which are often fatal. The increasing use of immunosuppressive therapy and the spread of AIDS has led to a steep increase in the incidence of fungal infections. Few effective and safe antifungal drugs are available and the frequency of drug-resistant fungal is increasing. Hence, new and effective antifungal drugs must be developed. The identification of new antifungal targets depends upon strong fundamental research programmes, which are the topics of this Conference Series.
This application requests funding for the second and the third meetings in a Conference Series on Human Fungal Pathogens. In September, 1999, the first conference in this series will deal with Fungal Morphogenesis and the Cell Wall. The EC does not provide support this conference, but the conference takes place because of the contribution from the ESF and a significant amount of industrial sponsorship. This support reflects the great relevance and interest in the emerging fungal threat to human health, and we now seek appropriate funding from the EC to continue the Conference Series.
The first of the two proposed conferences will address virulence factors which play central roles in fungal disease (fungal adhesion to host tissues, fungal enzymes which attack host tissue, and fungal cell shape). The second conference will focus on host-pathogen interactions (how the host responds to fungal invasion, how the fungal protects itself from host immune defences, and how human and fungal cells interact). A range of fungal pathogens will be discussed, thereby revealing common properties that might represent potential targets for new, broad-spectrum antifungal drugs. Both conferences will discuss these topics within the framework of rapid technological advances in fungal genomics and pharmacogenomics.
ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00137-1.pdf(opens in new window)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences microbiology mycology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Coordinator
Austria
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