Objective
Illness caused by bacterial infections is a major burden on the health care system and leads to significant economic loss through sick leave. The steady emergence of antibiotic resistant pathogen strains emphasises the necessity of maximising the defensive potential of natural immunity. In recent years there have been tremendous advances in understanding the ways in which the adaptive immune system deals with pathogens and there have been equally rapid advances in understanding the ways in which the so-called innate immune system holds infections in check. It is now clear that the two systems, far from being independent, are in fact tightly intermeshed so that a host pathogen interaction always involves components from both systems. Indeed it is at this interface between innate and adaptive immunity that the central decisions are taken which determine whether the host's attempts to fend off bacterial attack will succeed. Despite our increased understanding of the coordinated nature of the host response, attempts to develop new therapeutic strategies based on these insights have so far been disappointing.
The cause of these failures can in part be traced to the fact that innate and adaptive immunity have till now been largely treated as quite different subjects of investigation. As a consequence no major conferences are currently staged in Europe, which are directed to integrating our concepts of these two aspects of defence strategy. The objective of the proposed meetings is to provide a forum within which internationally recognised experts from both sides of the problem will discuss the mechanisms operating at the interface between innate and adaptive immunity. A better understanding of these mechanisms and their coordination will be essential in order that ways can be developed to manipulate the system to the patient's advantage.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.