Cytochromes P450 (abbrev. P450) are the most important enzymes of metabolism of drugs, environmental pollutants and many toxicants as chemical carcinogens (e.g. polycyclic aromatic hydrocarbons, nitrosamines). On the other hand, the P450s are also involved in many vital functions in the body such as in the biosynthesis of steroid hormones, prostaglandins or thromboxanes. Hence, the importance of this subject for understanding of molecular mechanisms of processes involved e.g. in hormone biosynthesis, drug metabolism or in the activation of chemical carcinogens is crucial.
This Conference is focussed:
(i) on the insight into the nature of structure/function relationship of the P450 enzymes;
(ii) on the role of P450 enzymes in situ, e.g. in the respective tisues as e.g. liver, lung, brain, kidney, heart;
(iii) on their functioning in drug metabolism.
The P450 genomics/proteomics will be part of the programme as well as P450 pharmacogenetics. The international community of P450 scientists meets in a 2-year interval, mostly in Europe (it was organised in the U.S.A. and Japan only exceptionally). This European tradition is stressed also by the usual composition of participants. The Czech Republic and Prague have been selected as the site of this Conference thanks to two advantages: First, its position in the heart of Europe and at the interface between the EU and Candidate or Associate states predisposes it as an ideal site for meeting of all the people interested in this field and, second, as a recognition of the position of Czech scientists in this field.